反应详情

A mixture of 3-amino-5-methylsulphamyl-4-phenoxy-benzoic acid (1 g), benzyl bromide (1.25 g), and dry ethanol (15 ml) was refluxed for 9 hours. After 3 hours and after 6 hours more benzyl bromide (0.6 g) was added. After cooling, the precipitated ethyl 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoate was collected by suction, recrystallized from ethanol, and dried in vacuo. The melting point of the compound was 162.5°C.

1. temperaturewas refluxed for 9 hours
2. temperatureAfter cooling
3. customthe precipitated ethyl 3-benzylamino-5-methylsulphamyl-4-phenoxy-benzoate was collected by suction
4. customrecrystallized from ethanol
5. customdried in vacuo
6. customwas 162.5°C.