Hydrochloric Acid → HCID 21505997, compound

HRID 918697Notes

Reaction equation

HRID 918697 reaction equation
[NH:1]([C:8]1[C:18]([S:19](=[O:28])(=[O:27])[NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][C:9]=1[NH:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[NH:1]([C:8]1[C:18]([S:19](=[O:28])(=[O:27])[NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:17][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[NH:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21506015HCID 21506015, compound

Product 1

HCID 21505997HCID 21505997, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 4-anilino-3-benzylamino-5-phenylsulphamyl-benzoate (3 g) was dissolved in 1N sodium hydroxide (35 ml), and the solution was heated on a steam bath for 1 hour. After cooling, the reaction mixture was adjusted to a pH of 2.5 by addition of 4N hydrochloric acid. The precipitated 4-anilino-3-benzylamino-5-phenylxulphamyl-benzoic acid was collected by suction and recrystallized from acetone/water. The compound was obtained with a melting point of 243°C.

Workup

  1. temperaturethe solution was heated on a steam bath for 1 hour
  2. temperatureAfter cooling
  3. customThe precipitated 4-anilino-3-benzylamino-5-phenylxulphamyl-benzoic acid was collected by suction
  4. customrecrystallized from acetone/water
  5. customThe compound was obtained with a melting point of 243°C.

Sources & evidence

ORD record
ord-cfe8ae96d93f4856b8d94930f28531b7
Source dataset
uspto-grants-1976_07
Patent number
US03971819

Reaction notes

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