1-Acetoxy-2-bromoethane → HCID 118020257, compound

HRID 918781Notes

Reaction equation

HRID 918781 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[Br:12][CH2:13][CH2:14][O:15][C:16](=[O:18])[CH3:17]>>[BrH:12].[C:16]([O:15][CH2:14][CH2:13][N:3]1[CH:4]=[C:5]([C:8]([F:9])([F:11])[F:10])[CH:6]=[CH:7][C:2]1=[NH:1])(=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 7358622-Amino-5-(trifluoromethyl)pyridine

Product 1

HCID 118020257HCID 118020257, compound

Conditions

Temperature
80 °C

Procedure

A mixture of 3.0 g of 2-amino-5-trifluoromethylpyridine and 7 ml of bromoethylacetate was stirred at 80° C. for 1 hour, and concentrated under reduced pressure. The resulting residue was suspended in a mixed solvent of acetonitrile and t-butyl methyl ether, and filtered. The resulting solid was washed with t-butyl methyl ether to obtain 2.46 g of (2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide.

Workup

  1. concentrationconcentrated under reduced pressure
  2. filtrationfiltered
  3. washThe resulting solid was washed with t-butyl methyl ether

Sources & evidence

ORD record
ord-69c1cfa414af479687d535c79a3cd49c
Source dataset
uspto-grants-2016_03
Patent number
US09271500B2

Reaction notes

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