2-Fluoro-5-(trifluoromethoxy)benzylamine → 6-Bromo-N-(2-fluoro-5-(trifluoromethoxy)benzyl)imidazo[1,2-a]pyridine-2-carboxamide

HRID 918828Notes

Reaction equation

HRID 918828 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[CH2:13][NH2:14].[Br:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([CH:22]=[C:23]([C:25](OCC)=[O:26])[N:24]=2)[CH:21]=1>>[Br:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([CH:22]=[C:23]([C:25]([NH:14][CH2:13][C:3]3[CH:4]=[C:5]([O:8][C:9]([F:11])([F:12])[F:10])[CH:6]=[CH:7][C:2]=3[F:1])=[O:26])[N:24]=2)[CH:21]=1

Participants

3

Reactant 2

HCID 37393022-Fluoro-5-(trifluoromethoxy)benzylamineHCID 7141939Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 1181139476-Bromo-N-(2-fluoro-5-(trifluoromethoxy)benzyl)imidazo[1,2-a]pyridine-2-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate I, using (2-fluoro-5-(trifluoromethoxy)phenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

Sources & evidence

ORD record
ord-32e750e570a842d290e83e223bce9667
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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