Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate → 6-Bromo-N-(4-chloro-2,6-difluorobenzyl)imidazo[1,2-a]pyridine-2-carboxamide

HRID 918860Notes

Reaction equation

HRID 918860 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH2:9][NH2:10])=[C:4]([F:11])[CH:3]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[C:20]([C:22](OCC)=[O:23])[N:21]=2)[CH:18]=1>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[C:20]([C:22]([NH:10][CH2:9][C:5]3[C:4]([F:11])=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=3[F:8])=[O:23])[N:21]=2)[CH:18]=1

Participants

3

Reactant 2

HCID 7141939Ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylateHCID 17750831(4-Chloro-2,6-difluorophenyl)methanamine

Product 1

HCID 1181138836-Bromo-N-(4-chloro-2,6-difluorobenzyl)imidazo[1,2-a]pyridine-2-carboxamide

Procedure

The title compound was prepared by using procedures analogous to those described for the synthesis of Intermediate I, using (4-chloro-2,6-difluorophenyl)methanamine and ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate as starting materials.

Sources & evidence

ORD record
ord-16fa3bd2bd84463596acdedc6ca89ecd
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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