2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid → 2-Bromo-N-(3-chloro-4-(trifluoromethoxy)benzyl)imidazo[2,1-b]thiazole-6-carboxamide

HRID 918866Notes

Reaction equation

HRID 918866 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:13][NH2:14])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24](O)=[O:25])=[CH:23][N:18]2[CH:17]=1>>[Br:15][C:16]1[S:20][C:19]2=[N:21][C:22]([C:24]([NH:14][CH2:13][C:4]3[CH:5]=[CH:6][C:7]([O:8][C:9]([F:11])([F:12])[F:10])=[C:2]([Cl:1])[CH:3]=3)=[O:25])=[CH:23][N:18]2[CH:17]=1

Participants

3

Reactant 2

HCID 127446152-Bromoimidazo[2,1-b]thiazole-6-carboxylic acidHCID 534144551-[3-Chloro-4-(trifluoromethoxy)phenyl]methanamine

Product 1

HCID 1181139012-Bromo-N-(3-chloro-4-(trifluoromethoxy)benzyl)imidazo[2,1-b]thiazole-6-carboxamide

Procedure

The title compound was prepared by essentially following the same procedures described for Intermediate XLVI, using (3-chloro-4-(trifluoromethoxy)phenyl)methanamine and 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-9ce2e8e86d5542aeb6850d95ab1b5cd8
Source dataset
uspto-grants-2016_03
Patent number
US09271969B2

Reaction notes

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