Sucrose → DL-Glutamic acid

HRID 918920Notes

Reaction equation

HRID 918920 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4]SC.C(O)[C@H]1[O:16][C@H:15]([O:17][C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>O>[CH2:3]([CH:2]([NH2:1])[C:7]([OH:9])=[O:8])[CH2:4][C:15]([OH:17])=[O:16]

Participants

4

Reactant 2

HCID 5988SucroseHCID 6137L-Methionine

Product 1

HCID 611DL-Glutamic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

An excipients solution is prepared according to a protocol similar to that of Preparation 3 using 0.02 g of methionine, 0.96 g of sucrose and 9.01 g of water for injection (WFI). 8.42 g of the previous excipients solution were added to 9.66 g of water for injection (WFI) and to 7.31 g of polymer P2 solution (46.7 mg/mL polymer P2 solution) obtained by the method described in Preparation 7. This solution was gently stiffed for at least 15 min at room temperature.

Workup

  1. customAn excipients solution is prepared
  2. customobtained by the method
  3. customdescribed in Preparation 7
  4. waitThis solution was gently stiffed for at least 15 min at room temperature

Sources & evidence

ORD record
ord-7d2f88b2c54e4c81978eb79b5e566014
Source dataset
uspto-grants-2016_03
Patent number
US09272020B2

Reaction notes

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