Dichloromethane → Trifluoroacetic acid

HRID 91893Notes

Reaction equation

HRID 91893 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH:8]([CH:9]2[CH2:10][N:11]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][CH2:24][NH:25][C:26](=[O:27])[O:28][CH3:29])[cH:5][cH:6][cH:7]1.[Cl:37][CH2:38][Cl:39].[F:30][C:31]([C:32](=[O:33])[OH:34])([F:35])[F:36]>>[Cl:1][c:2]1[cH:3][c:4]([CH:8]([CH:9]2[CH2:10][NH:11][CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][CH2:24][NH:25][C:26](=[O:27])[O:28][CH3:29])[cH:5][cH:6][cH:7]1.[F:30][C:31]([C:32](=[O:33])[OH:34])([F:35])[F:36]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58011484Tert-butyl 3-[(3-chlorophenyl)-[2-(methoxycarbonylamino)ethoxy]methyl]piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 68714190Carbamic acid, N-[2-[(R)-(3-chlorophenyl)(3R)-3-piperidinylmethoxy]ethyl]-, methyl ester

Sources & evidence

ORD record
ord-6082aa2958dd426795cc4adcc8094a52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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