1-Methylpiperazine → HCID 3151267, compound

HRID 918960Notes

Reaction equation

HRID 918960 reaction equation
[C:1]1([O:11][CH2:12][CH:13]2[CH2:15][O:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>C(O)C>[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:15][CH:13]([OH:14])[CH2:12][O:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 915212-((1-Naphthalenyloxy)methyl)oxirane

Product 1

HCID 3151267HCID 3151267, compoundYield 61.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-((1-naphthyloxy)methyl)oxirane (50 mg, 0.25 mmol) in ethanol (0.50 mL) was added 4-methylpiperazine (33 μL, 0.30 mmol) at room temperature. The mixture was stirred under reflux for 1 hr. The reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give HUHS1008 (46 mg, 61%).

Workup

  1. temperatureunder reflux for 1 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customThe crude product was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-dd09fddefdfb4691bdb9d5fef08681b2
Source dataset
uspto-grants-2016_03
Patent number
US09272980B2

Reaction notes

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