1-(4-Boronophenyl)cyclopropane-1-carboxylic acid → 1-{4'-[3-((R)-1-Phenyl-ethoxycarbonylamino)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

HRID 919046Notes

Reaction equation

HRID 919046 reaction equation
[C:1]1([C@H:7]([O:9][C:10]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][C:18]=2[C:19]2[CH:24]=[CH:23][C:22](OS(C(F)(F)F)(=O)=O)=[CH:21][CH:20]=2)=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B([C:36]1[CH:41]=[CH:40][C:39]([C:42]2([C:45]([OH:47])=[O:46])[CH2:44][CH2:43]2)=[CH:38][CH:37]=1)(O)O>>[C:1]1([C@H:7]([O:9][C:10]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][C:18]=2[C:19]2[CH:20]=[CH:21][C:22]([C:36]3[CH:41]=[CH:40][C:39]([C:42]4([C:45]([OH:47])=[O:46])[CH2:44][CH2:43]4)=[CH:38][CH:37]=3)=[CH:23][CH:24]=2)=[O:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 467396661-(4-Boronophenyl)cyclopropane-1-carboxylic acidHCID 86697087trifluoro-methanesulfonic acid 4-[3-((R)-1-phenyl-ethoxycarbonylamino)-pyridin-4-yl]-phenyl ester

Product 1

HCID 573861161-{4'-[3-((R)-1-Phenyl-ethoxycarbonylamino)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Procedure

Prepared according to the procedure described in Example 1, Step 2, using the following starting materials: trifluoro-methanesulfonic acid 4-[3-((R)-1-phenyl-ethoxycarbonylamino)-pyridin-4-yl]-phenyl ester and 1-(4-boronophenyl)cyclopropanecarboxylic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6ba083e555d04965b49d59894e483148
Source dataset
uspto-grants-2016_03
Patent number
US09272990B2

Reaction notes

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