HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-[1-(4-Bromophenyl)cyclopropyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-[1-(4-Bromophenyl)cyclopropyl]acetonitrile | HCID 66579314 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[1-(4-Bromophenyl)cyclopropyl]acetic acid | HCID 66577622 | — |
Reaction Steps
[1-(4-Bromo-phenyl)-cyclopropyl]-acetonitrile (from previous step) was dissolved in EtOH (50 mL) and H2O (6 mL). Potassium hydroxide (5.4 g, 96 mmol) was added and the reaction was heated to reflux overnight. After cooling the reaction was submitted to standard aqueous workup and purified on silica gel to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09272990B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-cce7871f1e1447a19adb7dc5820bf3e6 |
| Source note | uspto-grants-2016_03 |