1-(3-Bromo-thiophen-2-yl)-4-phenyl-butan-1-ol → (1-{4'-[2-(1-Hydroxy-4-phenyl-butyl)-thiophen-3-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid ethyl ester

HRID 919072Notes

Reaction equation

HRID 919072 reaction equation
Br[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]([OH:17])[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:18]([O:20][C:21](=[O:47])[CH2:22][C:23]1([C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][C:35](B4OC(C)(C)C(C)(C)O4)=[CH:34][CH:33]=3)=[CH:28][CH:27]=2)[CH2:25][CH2:24]1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:47])[CH2:22][C:23]1([C:26]2[CH:27]=[CH:28][C:29]([C:32]3[CH:37]=[CH:36][C:35]([C:2]4[CH:6]=[CH:5][S:4][C:3]=4[CH:7]([OH:17])[CH2:8][CH2:9][CH2:10][C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[CH:34][CH:33]=3)=[CH:30][CH:31]=2)[CH2:24][CH2:25]1)[CH3:19]

Participants

3

Reactant 2

HCID 679637651-(3-Bromo-thiophen-2-yl)-4-phenyl-butan-1-olHCID 67963776{1-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid ethyl ester

Product 1

HCID 67958069(1-{4'-[2-(1-Hydroxy-4-phenyl-butyl)-thiophen-3-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 2, using the following starting materials: 1-(3-bromo-thiophen-2-yl)-4-phenyl-butan-1-ol and {1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0ae324e2401e42528ee25fc2c6de38d5
Source dataset
uspto-grants-2016_03
Patent number
US09272990B2

Reaction notes

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