1-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester → HCID 67959556, compound

HRID 919087Notes

Reaction equation

HRID 919087 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:22]=[N:23][N:24]([CH3:34])[C:25]=4[NH:26]C(OC(C)(C)C)=O)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]>Cl>[CH2:1]([O:3][C:4]([C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:22]=[N:23][N:24]([CH3:34])[C:25]=4[NH2:26])=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 1

HCID 679596791-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Product 1

HCID 67959556HCID 67959556, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1-[4′-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester (0.49 g, 1.1 mmol) was dissolved in HCl (4 N in dioxane, 3 mL) and stirred at room temperature for 30 minutes. The reaction was concentrated to dryness to yield the title compound as the hydrochloride salt.

Workup

  1. concentrationThe reaction was concentrated to dryness

Sources & evidence

ORD record
ord-996835e451394706855624d75dbf0d33
Source dataset
uspto-grants-2016_03
Patent number
US09272990B2

Reaction notes

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