Cyclohexanecarboxylic acid → Cyclohexanecarbonyl chloride

HRID 919115Notes

Reaction equation

[CH:1]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:12]>>[CH:1]1([C:7]([Cl:12])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 7413Cyclohexanecarboxylic acid

HCID 24386Thionyl Chloride

Product 1

HCID 75938Cyclohexanecarbonyl chloride

Conditions

Temperature: 30 °C

Procedure

The mixture of cyclohexylcarboxylic acid (40 g) and SOCl2 (60 mL) was heated at 30° C. for 30 min and then at 50° C. for 3-5 hrs. The volatile materials were removed in vacuum and the residue was used for the next reaction without further purification.

Workup

customThe volatile materials were removed in vacuum
customthe residue was used for the next reaction without further purification

Sources & evidence

ORD record: ord-d600726b417f4254a73fe3ec0f5f232c
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09273005B2

Reaction notes

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