1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrazole → 2-Amino-5-(3-pyrazol-1-yl-phenyl)-N-pyridazin-4-yl-nicotinamide

HRID 919218Notes

Reaction equation

HRID 919218 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[N:9][CH:8]=1)=[O:5].CC1(C)C(C)(C)OB([C:26]2[CH:27]=[C:28]([N:32]3[CH:36]=[CH:35][CH:34]=[N:33]3)[CH:29]=[CH:30][CH:31]=2)O1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([N:32]3[CH:36]=[CH:35][CH:34]=[N:33]3)[CH:27]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[N:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 49612491-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrazoleHCID 710614712-amino-5-bromo-N-pyridazin-4-yl-nicotinamide

Product 1

HCID 710610622-Amino-5-(3-pyrazol-1-yl-phenyl)-N-pyridazin-4-yl-nicotinamide

Procedure

Reaction of 2-amino-5-bromo-N-pyridazin-4-yl-nicotinamide (see step 1 in the synthesis of “A16”) and 1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-pyrazole gives the compound “A18”;

Workup

  1. customgives the compound “A18”

Sources & evidence

ORD record
ord-bf5a1c3704db4471919b9719c888f9e8
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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