2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetamide → 2-Amino-5-(1-carbamoylmethyl-1H-pyrazol-4-yl)-N-pyridin-4-yl-nicotinamide

HRID 919225노트

반응식

HRID 919225 반응식
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].CC1(C)C(C)(C)OB([C:26]2[CH:27]=[N:28][N:29]([CH2:31][C:32]([NH2:34])=[O:33])[CH:30]=2)O1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:26]2[CH:27]=[N:28][N:29]([CH2:31][C:32](=[O:33])[NH2:34])[CH:30]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

참가 물질

3

반응물 2

HCID 569657342-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetamideHCID 62155416HCID 62155416, 화합물

생성물 1

HCID 710608492-Amino-5-(1-carbamoylmethyl-1H-pyrazol-4-yl)-N-pyridin-4-yl-nicotinamide

실험 절차

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-acetamide gives the compound “A25”; HPLC/MS: 0.94 min, [M+H]=338;

후처리

  1. customgives the compound “A25”
  2. custom0.94 min, [M+H]=338

출처 및 근거

ORD 기록
ord-cc4ce857b1424381ac711e33b0b06fec
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273029B2

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