4-(2-Carboxyethyl)benzeneboronic acid → HCID 71061007, compound

HRID 919232Notes

Reaction equation

HRID 919232 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].B([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[CH:23][CH:22]=1)(O)O>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[CH:23][CH:22]=2)=[CH:13][C:3]=1[C:4](=[O:5])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 38634844-(2-Carboxyethyl)benzeneboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71061007HCID 71061007, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 3-(4-boronophenyl)-propanoic acid gives the compound “A32”; HPLC/MS: 1.28 min, [M+H]=363;

Workup

  1. customgives the compound “A32”
  2. custom1.28 min, [M+H]=363

Sources & evidence

ORD record
ord-baafaa84b97646d19902aac9e181ba32
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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