Methylamine → 2-Amino-N-(3-methylcarbamoyl-pyridin-4-yl)-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide

Participants

Reaction Steps

100 mg of methyl 4-[[2-amino-5-[5-(morpholinomethyl)-2-thienyl]pyridine-3-carbonyl]amino]pyridine-3-carboxylate (MSC 2392368) are dissolved in 4 ml THF and 4 ml of methylamine (40% in water) are added. The mixture is stirred for 2 h at room temperature. The mixture is evaporated and treated with petrol ether and ethyl acetate. After filtration 79 mg of a yellow solid is obtained;

Provenance & Evidence