2-amino-5-bromo-N-(pyridin-4-yl)nicotinamide → HCID 71060960, compound

HRID 919244Notes

Reaction equation

HRID 919244 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].C([C:22]1[C:27]([S:28](=[O:31])(=[O:30])[NH2:29])=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O)(C)(C)C>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=2[S:28](=[O:30])(=[O:31])[NH:29][C:3]([CH3:13])([CH3:4])[CH3:2])=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamideHCID 67451655HCID 67451655, compound

Product 1

HCID 71060960HCID 71060960, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 2-tert.-butyl-sulfamoyl-benzeneboronic acid gives “A64”; method 1: HPLC/MS: 1.41 min, [M+H]=426;

Workup

  1. customgives “A64”
  2. custom1.41 min, [M+H]=426

Sources & evidence

ORD record
ord-a873e04690ec4a6e9182de046575712f
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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