4-Hydroxyphenylboronic acid → HCID 71062640, compound

HRID 919252Notes

Reaction equation

HRID 919252 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[OH:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:22]2[CH:23]=[CH:24][C:19]([OH:18])=[CH:20][CH:21]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 27343604-Hydroxyphenylboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71062640HCID 71062640, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 4-hydroxybenzene-boronic acid gives “A72”; method 1: HPLC/MS: 1.07 min, [M+H]=307;

Workup

  1. customgives “A72”
  2. custom1.07 min, [M+H]=307

Sources & evidence

ORD record
ord-bfacefe661994ad09c13cb7959fc5696
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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