HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 4-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid | HCID 71061416 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid | HCID 71060860 | — |
Reaction Steps
60 mg (0.18 mmol) of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid and 23.13 μl (0.22 mmol) of N-(methoxyethyl)methylamine are dissolved in 2 mL DMF. 102.36 mg HATU ((2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate) and 59.19 μL N-methylmorpholine are added to the solution. The mixture is stirred for 3 h at room temperature. The DMF is evaporated and the product is purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-e602f8aae6cc47809f20815ce88b64a8 |
| Source note | uspto-grants-2016_03 |