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HRID919263

反应详情

EQUATION

反应方程式

HRID 919263 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：CNCCOC
HCID300977

N-(2-Methoxyethyl)methylamine

C4H11NO

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

2 次

结构：Nc1ncc(-c2ccc(C(=O)O)cc2)cc1C(=O)Nc1ccncc1
HCID71061416

未命名化合物

PRODUCTS

生成物

1
结构：Nc1ncc(-c2ccc(C(=O)O)c(F)c2)cc1C(=O)Nc1ccncc1
HCID71060860

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

60 mg (0.18 mmol) of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid and 23.13 μl (0.22 mmol) of N-(methoxyethyl)methylamine are dissolved in 2 mL DMF. 102.36 mg HATU ((2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate) and 59.19 μL N-methylmorpholine are added to the solution. The mixture is stirred for 3 h at room temperature. The DMF is evaporated and the product is purified by chromatography.

WORKUP

后处理

  1. customThe DMF is evaporated
  2. customthe product is purified by chromatography