1,2-Ethanediamine, N1,N1,N2-trimethyl- → 2-Amino-5-{4-[(2-dimethylamino-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

HRID 919267Notes

Reaction equation

HRID 919267 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[CH3:26][N:27]([CH3:32])[CH2:28][CH2:29][NH:30][CH3:31]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](=[O:13])[N:30]([CH2:29][CH2:28][N:27]([CH3:32])[CH3:26])[CH3:31])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17]([NH:18][C:19]1[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=1)=[O:25]

Participants

3

Reactant 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 71061416HCID 71061416, compound

Product 1

HCID 710804022-Amino-5-{4-[(2-dimethylamino-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

Procedure

Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with N,N,N′-trimethylethylenediamine gives “A90”; method 2: HPLC/MS: 1.55 min, [M+H]419;

Workup

  1. customgives “A90”
  2. custom1.55 min, [M+H]419

Sources & evidence

ORD record
ord-a04941c203994bcd867ef0f6fc1fcf4d
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

Loading…