2-Methoxyethylamine → 2-Amino-5-[4-(2-methoxy-ethylcarbamoyl)-phenyl]-N-pyridin-4-yl-nicotinamide

HRID 919269Notes

Reaction equation

HRID 919269 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[CH3:26][O:27][CH2:28][CH2:29][NH2:30]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](=[O:13])[NH:30][CH2:29][CH2:28][O:27][CH3:26])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17]([NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=[O:25]

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 710614164-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid

Product 1

HCID 710608462-Amino-5-[4-(2-methoxy-ethylcarbamoyl)-phenyl]-N-pyridin-4-yl-nicotinamide

Procedure

Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with 2-methoxy-ethylamine gives “A92”; method 1: HPLC/MS: 1.25 min, [M+H]=392;

Workup

  1. customgives “A92”
  2. custom1.25 min, [M+H]=392

Sources & evidence

ORD record
ord-ae07cacb100248e58be6bf61339b00dc
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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