(2-Methoxyethyl)(methyl)amine → 2-Amino-5-{3-fluoro-4-[(2-methoxy-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

HRID 919278Notes

Reaction equation

HRID 919278 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[C:10]([F:17])[CH:9]=2)=[CH:4][C:3]=1[C:18](=[O:26])[NH:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1.[CH3:27][O:28][CH2:29][CH2:30][NH:31][CH3:32]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](=[O:14])[N:31]([CH2:30][CH2:29][O:28][CH3:27])[CH3:32])=[C:10]([F:17])[CH:9]=2)=[CH:4][C:3]=1[C:18]([NH:19][C:20]1[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=1)=[O:26]

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 710608604-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid

Product 1

HCID 710802322-Amino-5-{3-fluoro-4-[(2-methoxy-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

Procedure

Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid with N-(methoxyethyl)-methylamine gives “A102”; method 1: HPLC/MS: 1.34 min, [M+H]=424;

Workup

  1. customgives “A102”
  2. custom1.34 min, [M+H]=424

Sources & evidence

ORD record
ord-c5f3ab1e1cec49609a66ee6570439410
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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