HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxyethyl)(methyl)amine → 2-Amino-5-{3-fluoro-4-[(2-methoxy-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| Reactant | 4-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid | HCID 71060860 | — |
| Product | 2-Amino-5-{3-fluoro-4-[(2-methoxy-ethyl)-methyl-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide | HCID 71080232 | — |
Reaction Steps
Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-2-fluoro-benzoic acid with N-(methoxyethyl)-methylamine gives “A102”; method 1: HPLC/MS: 1.34 min, [M+H]=424;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c5f3ab1e1cec49609a66ee6570439410 |
| Source note | uspto-grants-2016_03 |