HCID 117653658, compound → HCID 90421591, compound

HRID 919372Notes

Reaction equation

HRID 919372 reaction equation
[O:1]1[CH2:4][CH:3]([N:5]2[CH2:10][CH2:9][CH:8]([CH:11]3[CH2:16][CH2:15][N:14](C(OCC4C=CC=CC=4)=O)[CH2:13][CH2:12]3)[CH2:7][CH2:6]2)[CH2:2]1>CO.[Pd]>[O:1]1[CH2:2][CH:3]([N:5]2[CH2:10][CH2:9][CH:8]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:7][CH2:6]2)[CH2:4]1

Participants

4

Reactant 1

HCID 117653658HCID 117653658, compound

Product 1

HCID 90421591HCID 90421591, compoundYield 114.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

520 mg (1.45 mmol) of benzyl 1′-(oxetan-3-yl)-[4,4′-bipiperidine]-1-carboxylate was dissolved in 30 ml methanol and hydrogenated in the H-cube® flow hydrogenator using a 10 mol % Pd (C) cartridge at a flow rate of 1 ml/min. The solvent was removed in vacuo providing 372 mg of the title compound which was used without further purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-e9d517f436d44504ba4b6ce5cc57b52a
Source dataset
uspto-grants-2016_03
Patent number
US09273036B2

Reaction notes

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