反应详情

温度

60 °C

To a stirred solution of ester product of Step A (360 mg, 0.98 mmol) in THF (3 mL) and methanol (3 mL) was added sodium hydroxide aqueous solution (1 mL, 2 M, 2 mmol) at room temperature. The mixture was stirred at 60° C. for 2 hrs. The solvent was removed under reduced pressure and the residue was dissolved into water (5 mL). The solution was neutralized with HCl (2 mol/L) to pH=7 and white solid precipitated out of solution. The white solid was collected by filtration and dried in air to give the title compound (230 mg, 69.3%).

1. customThe solvent was removed under reduced pressure
2. dissolutionthe residue was dissolved into water (5 mL)
3. customprecipitated out of solution
4. filtrationThe white solid was collected by filtration
5. customdried in air