Ethanol → HCID 66931525, compound

HRID 920137Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8](=O)[CH3:9])[CH:7]=1.[C-]#N.[K+].[C:15](=[O:18])([O-])[O-].[NH4+:19].[NH4+:20].[CH2:21]([OH:23])C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8]2([CH3:9])[NH:20][C:21](=[O:23])[NH:19][C:15]2=[O:18])[CH:7]=1

Participants

Reactant 4

HCID 702Ethanol

HCID 9032Potassium Cyanide

HCID 517111Ammonium Carbonate

HCID 226074761-(5-Bromo-2-fluorophenyl)ethanone

Product 1

HCID 66931525HCID 66931525, compound

Procedure

The reaction of commercially available 1-(5-bromo-2-fluoro-phenyl)-ethanone with potassium cyanide and ammonium carbonate in ethanol in an autoclave at 120° C. for 16 h yielded the title compound as light yellow solid. Mass (calculated) C10H8BrFN2O2 [287.087]; (found) [M−H]−=285, 287.

Sources & evidence

ORD record: ord-50464664c3bb45d694360d81762ef9c9
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09273042B2

Reaction notes

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