Sodium Hydroxide → HCID 60795560, compound

HRID 920140Notes

Reaction equation

HRID 920140 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([CH3:15])[NH:12]C(=O)N[C:9]1=[O:14].[OH-].[Na+].NC(C1C=CC=CC=1F)(C)[C:20](O)=[O:21].S(Cl)(Cl)=O>CO>[CH3:20][O:21][C:9](=[O:14])[C:8]([NH2:12])([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])[CH3:15]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 24386Thionyl ChlorideHCID 2381237248-25-1HCID 36147732-amino-2-(2-fluorophenyl)propanoic Acid

Product 1

HCID 60795560HCID 60795560, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The hydrolysis of the (RS)-5-(2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione with 3 N sodium hydroxide solution and esterification of the resulting (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid with methanol and thionylchloride yielded the (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid methylester as a light yellow liquid. The purity of the product allowed using it in the next step without further purification. MS (ISP): m/z=198.2 [M+H]+.

Sources & evidence

ORD record
ord-87b4efd426ec4f73b12bdef19cd8916f
Source dataset
uspto-grants-2016_03
Patent number
US09273042B2

Reaction notes

Loading…