HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 60795560, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7248-25-1 | HCID 238123 | — |
| Reactant | 2-amino-2-(2-fluorophenyl)propanoic Acid | HCID 3614773 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 60795560 | HCID 60795560 | — |
Reaction Steps
The hydrolysis of the (RS)-5-(2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione with 3 N sodium hydroxide solution and esterification of the resulting (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid with methanol and thionylchloride yielded the (RS)-2-amino-2-(2-fluoro-phenyl)-propionic acid methylester as a light yellow liquid. The purity of the product allowed using it in the next step without further purification. MS (ISP): m/z=198.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273042B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-87b4efd426ec4f73b12bdef19cd8916f |
| Source note | uspto-grants-2016_03 |