HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920285Generated: October 26, 2026
Potassium Carbonate → 3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)benzaldehyde
https://huagongshe.com/reaction/920285
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,4,5-Trifluorobenzaldehyde | HCID 2776954 | — |
| Reactant | 5-Hydroxy-2-(trifluoromethyl)pyridine | HCID 2783388 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)benzaldehyde | HCID 86676365 | 94% |
Reaction Steps
3,4,5-trifluorobenzaldehyde (1 g, 6.25 mmol), which is commercially available 6-(trifluoromethyl)-3-pyridinol (1.019 g, 6.25 mmol) and K2CO3 (1.727 g, 12.49 mmol) were added into a microwave vial. Then, N,N-dimethylformamide (DMF) (15 mL) was added. The microwave vial was sealed and heated in Biotage Initiator at 100° C. for 1 h. The mixture was extracted with by EtOAc. The organic extracts were dried over Na2SO4 and evaporated to give 1.78 g of the title product (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273054B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-a3db273e9c88422893768e48912f1c52 |
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| Source note | uspto-grants-2016_03 |
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