反应详情

温度

100 °C

3,4,5-trifluorobenzaldehyde (1 g, 6.25 mmol), which is commercially available 6-(trifluoromethyl)-3-pyridinol (1.019 g, 6.25 mmol) and K2CO3 (1.727 g, 12.49 mmol) were added into a microwave vial. Then, N,N-dimethylformamide (DMF) (15 mL) was added. The microwave vial was sealed and heated in Biotage Initiator at 100° C. for 1 h. The mixture was extracted with by EtOAc. The organic extracts were dried over Na2SO4 and evaporated to give 1.78 g of the title product (94%).

1. additionwere added into a microwave vial
2. customThe microwave vial was sealed
3. extractionThe mixture was extracted with by EtOAc
4. dry with materialThe organic extracts were dried over Na2SO4
5. customevaporated