反应详情

To a solution of 3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde (1.78 g, 5.87 mmol) in methanol (15 mL) was added NaBH4 (0.222 g, 5.87 mmol). The mixture was stirred at room temp for 0.5 h. NH4Cl solution was added to the reaction mixture, and the reaction mixture was extracted by DCM. The organic phase was then dried over Na2SO4 and evaporated to give the product (1.702 g, 95%).

1. extractionthe reaction mixture was extracted by DCM
2. dry with materialThe organic phase was then dried over Na2SO4
3. customevaporated