Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → (3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)phenyl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)benzaldehyde | HCID 86676365 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (3,5-Difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)phenyl)methanol | HCID 66825487 | 95% |
반응 단계
To a solution of 3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde (1.78 g, 5.87 mmol) in methanol (15 mL) was added NaBH4 (0.222 g, 5.87 mmol). The mixture was stirred at room temp for 0.5 h. NH4Cl solution was added to the reaction mixture, and the reaction mixture was extracted by DCM. The organic phase was then dried over Na2SO4 and evaporated to give the product (1.702 g, 95%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09273054B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-ab5404f3f6314f2cba81ed55e941432d |
| 출처 메모 | uspto-grants-2016_03 |