3-Hydroxypyridine → HCID 66825616, compound

HRID 920326Notes

Reaction equation

HRID 920326 reaction equation
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[C:7]([CH:10]=1)[C:8]#[N:9])=[O:2].N1C=CC=C(O)C=1.FC1C=CC(C=O)=CC=1C#N>>[OH:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[C:7]([CH:10]=1)[C:8]#[N:9]

Participants

4

Reactant 3

HCID 79713-HydroxypyridineHCID 27695822-Fluoro-5-formylbenzonitrileHCID 86676378HCID 86676378, compound

Product 1

HCID 66825616HCID 66825616, compound

Procedure

The title compound was prepared by a procedure similar to that described for D5 starting from 5-formyl-2-(pyridine-3-yloxy)benzonitrile, which was prepared by reaction of pyridine-3-ol and 2-fluoro-5-formylbenzonitrile by the similar procedure to that described for D4.

Sources & evidence

ORD record
ord-3ad6806bbe6a4dd7b9f39bee25ab8860
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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