4-Chloro-3-(trifluoromethyl)benzyl alcohol → 8-((4-chloro-3-(trifluoromethyl)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920375Notes

Reaction equation

HRID 920375 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].Cl[C:15]1[CH:25]=[C:19]2[N:20]([CH3:24])[CH2:21][CH2:22][CH2:23][N:18]2[C:17](=[O:26])[N:16]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:15]2[CH:25]=[C:19]3[N:20]([CH3:24])[CH2:21][CH2:22][CH2:23][N:18]3[C:17](=[O:26])[N:16]=2)=[CH:4][C:3]=1[C:10]([F:11])([F:12])[F:13]

Participants

3

Reactant 2

HCID 27781114-Chloro-3-(trifluoromethyl)benzyl alcoholHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712366168-((4-chloro-3-(trifluoromethyl)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (4-chloro-3-(trifluoromethyl)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-7bd88db1de6e4369bb2e1df6016131f1
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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