2-(2,4-Difluorophenyl)ethanol → 8-[2-(2,4-Difluoro-phenyl)-ethoxy]-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

HRID 920400Notes

Reaction equation

HRID 920400 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][OH:11].Cl[C:13]1[CH:23]=[C:17]2[N:18]([CH3:22])[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:24])[N:14]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][O:11][C:13]1[CH:23]=[C:17]2[N:18]([CH3:22])[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:24])[N:14]=1

Participants

3

Reactant 2

HCID 534034612-(2,4-Difluorophenyl)ethanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712365708-[2-(2,4-Difluoro-phenyl)-ethoxy]-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E11 starting from 2-(2,4-difluorophenyl)ethanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-a09fcb2d982247d7a5c2a5b6be50df3e
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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