(4-Chloro-3-fluorophenyl)methanamine → 8-(4-Chloro-3-fluoro-benzylamino)-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

HRID 920418Notes

Reaction equation

HRID 920418 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][C:3]=1[F:10].Cl[C:12]1[CH:22]=[C:16]2[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]2[C:14](=[O:23])[N:13]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:12]2[CH:22]=[C:16]3[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]3[C:14](=[O:23])[N:13]=2)=[CH:4][C:3]=1[F:10]

Participants

3

Reactant 2

HCID 2757541(4-Chloro-3-fluorophenyl)methanamineHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712368308-(4-Chloro-3-fluoro-benzylamino)-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E59 starting from (4-chloro-3-fluorophenyl)methanamine and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-f8b617d3fe6449fbb45dbb04e4d39fa4
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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