(4-(3-(Trifluoromethyl)phenoxy)phenyl)methanol → 1-methyl-8-((4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920425Notes

Reaction equation

HRID 920425 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.Cl[C:21]1[CH:31]=[C:25]2[N:26]([CH3:30])[CH2:27][CH2:28][CH2:29][N:24]2[C:23](=[O:32])[N:22]=1>>[CH3:30][N:26]1[CH2:27][CH2:28][CH2:29][N:24]2[C:23](=[O:32])[N:22]=[C:21]([O:14][CH2:13][C:10]3[CH:9]=[CH:8][C:7]([O:6][C:5]4[CH:15]=[CH:16][CH:17]=[C:3]([C:2]([F:18])([F:19])[F:1])[CH:4]=4)=[CH:12][CH:11]=3)[CH:31]=[C:25]12

Participants

3

Reactant 2

HCID 66825531(4-(3-(Trifluoromethyl)phenoxy)phenyl)methanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712365751-methyl-8-((4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (4-(3-(trifluoromethyl)phenoxy)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-d36166907fdb4f31906adec402e95c02
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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