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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920425Generated: November 1, 2026

(4-(3-(Trifluoromethyl)phenoxy)phenyl)methanol → 1-methyl-8-((4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

https://huagongshe.com/reaction/920425

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-(3-(Trifluoromethyl)phenoxy)phenyl)methanolHCID 66825531—
Reactant8-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-oneHCID 71743471—
Product1-methyl-8-((4-(3-(trifluoromethyl)phenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 71236575—

Reaction Steps

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (4-(3-(trifluoromethyl)phenoxy)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273054B2
Source datasetuspto-grants-2016_03
ORD IDord-d36166907fdb4f31906adec402e95c02
Source noteuspto-grants-2016_03