8-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one → 8-((4-((6-chloropyridin-3-yl)oxy)-3-fluorobenzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920439Notes

Reaction equation

HRID 920439 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:10]=2[F:17])=[CH:4][CH:3]=1.Cl[C:19]1[CH:29]=[C:23]2[N:24]([CH3:28])[CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:30])[N:20]=1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:19]3[CH:29]=[C:23]4[N:24]([CH3:28])[CH2:25][CH2:26][CH2:27][N:22]4[C:21](=[O:30])[N:20]=3)=[CH:11][C:10]=2[F:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-oneHCID 86676396(4-((6-Chloropyridin-3-yl)oxy)-3-fluorophenyl)methanol

Product 1

HCID 866763958-((4-((6-chloropyridin-3-yl)oxy)-3-fluorobenzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (4-((6-chloropyridin-3-yl)oxy)-3-fluorophenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-9566fee4217544e7abb168fc0b438111
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

Loading…