2-(4-(4-Chloro-3-fluorophenoxy)-3-fluorophenyl)ethanol → 8-(4-(4-chloro-3-fluorophenoxy)-3-fluorophenethoxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920442Notes

Reaction equation

HRID 920442 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][OH:15])=[CH:9][C:8]=2[F:16])=[CH:4][C:3]=1[F:19].Cl[C:21]1[CH:31]=[C:25]2[N:26]([CH3:30])[CH2:27][CH2:28][CH2:29][N:24]2[C:23](=[O:32])[N:22]=1>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][O:15][C:21]3[CH:31]=[C:25]4[N:26]([CH3:30])[CH2:27][CH2:28][CH2:29][N:24]4[C:23](=[O:32])[N:22]=3)=[CH:9][C:8]=2[F:16])=[CH:4][C:3]=1[F:19]

Participants

3

Reactant 2

HCID 712365732-(4-(4-Chloro-3-fluorophenoxy)-3-fluorophenyl)ethanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712366898-(4-(4-chloro-3-fluorophenoxy)-3-fluorophenethoxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from 2-(4-(4-chloro-3-fluorophenoxy)-3-fluorophenyl)ethanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-0fd8681330da49de9ce7d85720a030a1
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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