Hydrochloric Acid → HCID 136340648, compound

HRID 920485Notes

Reaction equation

HRID 920485 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8]C)[C:3]=1[C:10]1[NH:29][C:13]2=[CH:14][C:15]3[C:16](=[O:28])[N:17]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[C:18](=[O:22])[C:19]=3[C:20]([CH3:21])=[C:12]2[N:11]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[C:10]1[NH:29][C:13]2=[CH:14][C:15]3[C:16](=[O:28])[N:17]([CH2:23][CH2:24][N:25]([CH3:26])[CH3:27])[C:18](=[O:22])[C:19]=3[C:20]([CH3:21])=[C:12]2[N:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 666871562-(4-Chloro-2-methoxypyridin-3-yl)-6-(2-(dimethylamino)ethyl)-4-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione

Product 1

HCID 136340648HCID 136340648, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
47.5 °C

Procedure

A solution of 2-(4-chloro-2-methoxypyridin-3-yl)-6-(2-(dimethylamino)ethyl)-4-methylimidazo[4,5-f]isoindole-5,7(1H,6H)-dione in a mixture of 1,4-dioxane (14 mL) and concentrated HCl (2.5 mL) was heated at 45-50° C. for 14 h. After the end of reaction was established by TLC, the reaction mixture was concentrated under vacuum to afford a crude product as a yellow solid, which was used for the next step without further purification. Mass (ESI, positive) m/z 400.1 [M+H]+.

Workup

  1. customAfter the end of reaction
  2. concentrationthe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-84b85ddaeaa04e368b62f12055e5fe58
Source dataset
uspto-grants-2016_03
Patent number
US09273055B2

Reaction notes

Loading…