Benzyl 3-fluoro-2-(fluoromethyl)-2-methylpropanoate → 3-Fluoro-2-(fluoromethyl)-2-methylpropanoic acid

To a stirred solution of Intermediate 209A (0.300 g, 1.314 mmol) in EtOAc (5 mL) was added 10% Pd/C (0.140 g, 0.131 mmol). The reaction mixture was stirred for 12 h under an atmosphere of hydrogen (15 psi). The reaction mixture was then filtered through a pad of CELITE® and the cake was washed with EtOAc. The filtrate was concentrated under reduced pressure to afford Intermediate 209B as a yellow liquid (160 mg, 88%). The crude product was used without further purification. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.02 (bs, 1H), 4.40-4.66 (m, 4H), 1.06-1.20 (m, 3H).

1. filtrationThe reaction mixture was then filtered through a pad of CELITE®
2. washthe cake was washed with EtOAc
3. concentrationThe filtrate was concentrated under reduced pressure

ORD record

ord-2358fd7b239647bbbdf4a346b3ba8091

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09273058B2