反应详情

温度

25 °C

2LiCl (2a prepared above; 2.64 g, 7.50 mmol) is placed in a 25 mL Schlenk-flask, dried for 5 min at 400° C. (heat gun) in high vacuum and then dissolved in dry THF (10.0 mL). 1-Bromo-3-(trifluoromethyl)benzene (3d; 1.13 g, 5.00 mmol) and magnesium-turnings (304 mg, 12.5 mmol) are added and the mixture was stirred for 2 h at 25° C. The solution is cannulated to a dry and argon-flushed 50 mL Schlenk-tube via syringe filter and the solvent is removed in vacuo. 3-(Trifluoromethyl)phenylzinc pivalate (1d) is obtained as a grey solid (3.72 g).

1. customis placed in a 25 mL Schlenk-flask
2. customdried for 5 min at 400° C.
3. temperature(heat gun) in high vacuum
4. dissolutiondissolved in dry THF (10.0 mL)
5. customa dry
6. customargon-flushed 50 mL Schlenk-tube via syringe
7. filtrationfilter
8. customthe solvent is removed in vacuo