Zinc → HCID 178447613, compound

Temperature

22 °C

Zinc powder (490 mg, 7.5 mmol) and LiCl (318 mg, 7.5 mmol) were placed in a Schlenk-flask, equipped with a magnetic stirrer and a septum, dried for 5 min at 400° C. (heat gun) in high vacuum and then dissolved in 7.0 mL of dry THF. 4 drops of 1,2-dibromoethane were added and the mixture was heated to boiling for the activation of the zinc dust. After cooling to 22° C. 3-iodopropionitrile (905 mg, 5.0 mmol) was added dropwise and the mixture was stirred for 2 h at 22° C. The stirring of the reaction mixture was stopped and the excess zinc dust was sedimented. The supernatant solution was transferred to another Schlenk-flask containing a solution of lithium pivalate (811 mg, 1.50 mmol) prepared as described above in 5.0 mL of dry THF. The mixture was stirred for 15 min at 22° C. and then the solvent was removed in vacuo. (2-cyanoethyl)zinc pivalate was obtained as a yellow solid (2.94 g). The content of active zinc species was determined by titration of 398 mg of the reagent with a stock solution of iodine (1.0 M in THF). A concentration of 1020 mg/mmol was determined which corresponds to a yield of 58%.

1. customequipped with a magnetic stirrer
2. customa septum, dried for 5 min at 400° C.
3. temperature(heat gun) in high vacuum
4. dissolutiondissolved in 7.0 mL of dry THF
5. addition4 drops of 1,2-dibromoethane were added
6. temperaturethe mixture was heated
7. stirringThe stirring of the reaction mixture
8. customThe supernatant solution was transferred to another Schlenk-flask
9. customprepared
10. stirringThe mixture was stirred for 15 min at 22° C.
11. customthe solvent was removed in vacuo

ORD record

ord-e295bdb83de64f3b9d7b57031f23642e

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09273070B2