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温度

0 °C

In a dry and argon-flushed Schlenk-flask, equipped with a magnetic stirring bar and a septum, ethyl 3-((tert-butoxycarbonyl)oxy)benzoate (266 mg, 1.00 mmol) was dissolved in dry THF (3.0 mL). TMPMgCl.LiCl (1.00 mL, 1.2 M in THF, 1.20 mmol) was added dropwise and the mixture was stirred for 4 h at 0° C. A solution of Zn(OPiv)2.2 LiCl (529 mg, 1.50 mmol) in 1.5 mL of dry THF was added and the mixture was slowly warmed to 22° C. The solvent was removed in vacuo and (2-((tert-butoxycarbonyl)oxy)-6-(ethoxycarbonyl)phenyl)zinc pivalate was obtained as a orange solid.

1. customIn a dry
2. customargon-flushed Schlenk-flask
3. customequipped with a magnetic stirring bar
4. temperaturethe mixture was slowly warmed to 22° C
5. customThe solvent was removed in vacuo