Hydrazine hydrate (1:1) → HCID 86683120, compound

HRID 920906Notes

Reaction equation

HRID 920906 reaction equation
C([O:3][C:4]([C:6]1[C:10]([Br:11])=[CH:9][S:8][C:7]=1[CH:12]=O)=O)C.[NH2:14][NH2:15].O>CCO>[Br:11][C:10]1[C:6]2[C:4](=[O:3])[NH:15][N:14]=[CH:12][C:7]=2[S:8][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 84819476HCID 84819476, compound

Product 1

HCID 86683120HCID 86683120, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Bromo-2-formyl-thiophene-3-carboxylic acid ethyl ester (1.0 g, 3.8 mmol), NH2NH2.H2O (0.27 g, 4.58 mmol) and 20 mL of EtOH were refluxed under nitrogen for 5 h. The reaction mixture was cooled and precipitate formed, then filtered to give the title compound (0.2 g, yield: 23%).

Workup

  1. temperatureThe reaction mixture was cooled
  2. customprecipitate formed
  3. filtrationfiltered

Sources & evidence

ORD record
ord-8537afce266c47388efaf008aa19bebe
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

Loading…