Ammonium Hydroxide → HCID 68011891, compound

HRID 920963Notes

Reaction equation

HRID 920963 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[C:5]([C:12]([O-])=[O:13])[N:4]=1.[OH-].[NH4+:18]>>[F:1][C:2]([F:16])([F:15])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[C:5]([C:12]([NH2:18])=[O:13])[N:4]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 86685642HCID 86685642, compound

Product 1

HCID 68011891HCID 68011891, compound

Conditions

Temperature
100 °C

Procedure

Methyl 3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate 3b (250 mg, 1 mmol) and 10 mL of ammonium hydroxide were added in a 20 mL sealed tube. The reaction mixture was heated to 100° C. and reacted for 3 hours. The reaction mixture was concentrated under reduced pressure to obtain crude 3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 10a (240 mg) as a white solid. The product was used directly in the next reaction without purification.

Workup

  1. customsealed tube
  2. customreacted for 3 hours
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6be1f3562ac94734b0ebc8c5481ba2d9
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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